To explore the mechanism of Jidou Zhike Powder(JDZK) in the treatment of chronic obstructive pulmonary disease(COPD) by network pharmacology.Methods:Therapeutic targets of JDZK on COPD were predicted by the databases and gene microarray.According to the calculation of contribution index,degree,betweenness,and closeness,the core compounds and therapeutic targets were chosen in the compound-target network(C-T) and the target-disease(T-D) network.Furthermore,therapeutic targets underwent enrichment analysis.Finally,the binding capacity between the core compounds and targets was verified by molecular docking.Results:A total of 116 therapeutic targets were obtained by prediction.In addition,two core compounds and five core targets were obtained in the C-T network and the T-D network according to the contribution index,degree,betweenness,and closeness.Furthermore,GO and KEGG analyses indicated that JDZK acted on COPD from inflammation,oxidative stress,cell apoptosis,infection resistance,and nutrition metabolism.Tissue enrichment analysis indicated that the therapeutic targets were enriched in multiple organs and tissues.Molecular docking results manifested excellent binding capacity between core compounds and core targets.Conclusion:JDZK treatment of COPD is characterized by multiple components and targets,which can prevent and cure COPD at multiple levels theoretically.