To explore the mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis by network pharmacology.Methods:The components and targets of Xiangsha Liujunzi Decoction were searched from TCMSP,and the drug-component-target network was plotted.Disease-related genes were screened out from GeneCards and OMIM for plotting the Venn diagram.The protein-protein interaction(PPI) network was delineated based on common genes for network topology analysis,and core genes were obtained.Gene Ontology(GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses were performed on the core genes.Results:After the screening,137 active components of Xiangsha Liujunzi Decoction,162 potential targets,702 related targets for chronic atrophic gastritis,and 51 common targets were obtained.Eighteen core targets,such as PTGS2,TNF,VEGFA,IL-1B,and CAT were obtained by network topology analysis,which were mainly enriched in biological processes,such as the response to reactive oxygen species and cell response to oxidative stress,and signaling pathways,such as TNF,IL-17,Toll-like receptor,and C-type lectin receptor,according to GO and KEGG analyses.Conclusion:Xiangsha Liujunzi Decoction can treat chronic atrophic gastritis through multi-component,multi-target,and multi-pathway,and inhibit the “inflammation-cancer” transformation of chronic atrophic gastritis.