To explore the compatibility and mechanism of traditional Chinese medicine in the treatment of coronary heart disease based on the methods of data mining and network pharmacology.Methods:Prescriptions for coronary heart disease were screened from the data set v1.0 provided by the national population and health science data sharing platform.Data mining was carried out through software such as SPSS Statistics 25.0，SPSS Modeler 14.1，etc.，and the rule of medication of traditional Chinese medicine(TCM) for the treatment of coronary heart disease was summarized.TCMSP，GeneCards and other databases were used to screen the active ingredients，targets of action and coronary heart disease-related targets of core drugs，and Cytoscape 3.2.7 software was used to construct a network diagram of “effective active ingredients-targets-disease” of core drugs for the treatment of coronary heart disease; David database was used for GO and KEGG enrichment analysis; Results:A total of141 prescriptions were screened，and 313 Chinese medicinals were obtained.The top 10 drugs were Radix et Rhizoma Glycyrrhizae，Radix et Rhizoma Ginseng，Radix Angelicae Sinensis，Poria，Cortex Cinnamomi，Radix Paeoniae Alba，Rhizoma Atractylodis Macrocephalae，Pericarpium Citri Reticulatae，Rhizoma Chuanxiong，Rhizoma Zingiberis.A total of 8 common factors were obtained by factor analysis，the core drug “Angelica sinensis-Radix Paeoniae Alba-Ligusticum wallichii” was obtained by association rule analysis.A total of 24 active components and 5 core targets were obtained by network pharmacology analysis of core drugs.KEGG enrichment pathway was mainly in MAPK signaling pathway，Toll-like receptor signaling pathway，PI3K-AKT signaling pathway，TNF signaling pathway etc.Conclusion:In ancient times,ancient physicians treats coronary heart disease by Chinese medicinal of tonifying deficiency，regulating qi and promoting blood circulation to remove blood stasis.The core drugs mainly regulate the expression of AKT1，mapk1，PI3K-AKT signaling pathway and Toll-like receptor signaling pathway to treat coronary heart disease.