Meridians and collaterals system is not only a bio-information system,but also is a physical-chemistry system.In this paper,it is aimed to investigate and establish mathematical pattern of propagation and transmission of biological signal in meridians.Methods:Based on biological heredity and variation information equation together with physical-chemistry principle,the bio-signal transmit equation and apparent permeability pressure formula were built up.Permeability pressure was claimed to be the major biological information source and transmit power.Results:With the novel approach,the quantitative relationship between transmission efficiency of bio-information and parameters Pg and k were determined,where Pg was the similarity and k was the degree of symmetry between internal and external mediums of body cells.Theoretical analysis indicated that meridians and collaterals had the highest biological information conduction efficiency,when Pg was in the range of 0.002 to 0.01,k between 0.001 to 0.01,and the apparent permeability pressure in the range of 0.4 to 5 MPa,which was safe to biological tissue.Conclusion:This novel theory is able to effectively explain many experiment results and phenomenons in experimental acupuncture,and supply scientific micro mechanism to meridian conduction.