Diabetic nephropathy is one of the serious complications of diabetes.Its incidence rate in China is increasing year by year.Due to serious metabolic disorders,it is the main cause of end-stage renal disease and renal failure.Therefore,early prevention and treatment of diabetic nephropathy are important,but there have been no breakthrough treatments.Shenyan Kangfu Tablets,the modified formula of Shenqi Pills derived from Synopsis of the Golden Chamber(Jin Gui Yao Lue),are currently one of the few clinical available drugs for the treatment of chronic kidney diseases,with the effects of replenishing qi and nourishing yin,clearing away heat and removing toxins,inducing diuresis to alleviate edema,and tonifying the kidney.They can repair damaged glomerular podocytes,regulate body immunity,reduce urine protein,and improve renal functions.As revealed by recent research,Shenyan Kangfu Tablets combined with conventional treatment showed good prognosis in the treatment of diabetic nephropathy.The present study summarized the chemical composition,clinical application,and pharmacological action of Shenyan Kangfu Tablets based on the relevant literature,and introduced the mechanism of Shenyan Kangfu Tablets in the treatment of diabetic nephropathy in light of the latest research progress,which was mainly related to the improvement of insulin resistance,reduction of inflammatory reaction,and regulation of intestinal flora abundance.This study is expected to provide data and theoretical support for the pathogenesis of diabetic nephropathy and the development of therapeutic drugs.