Traditional Chinese medicine(TCM)is effective in the treatment of bone-related diseases，and its molecular biological mechanism has become a hotspot.The abnormal differentiation of osteoclasts leads to a series of bone-related diseases.Research on the regulation of osteoclast differentiation through NF-κB signaling pathway in TCM has made a lot of progress.This paper summarizes the research status of the regulation of osteoclast differentiation based on the NF-κB signaling pathway in traditional Chinese medicine，elaborates the molecular biological mechanism，points out the current research deficiencies and future research directions，and expands the thinking for the treatment of bone-related diseases in TCM.