With the development of the society and the economy,people's life rhythm is accelerating and work pressure is increasing.The number of patients with functional constipation(FC) as well as anxiety and depression is increasing,the two conditions affecting each other.Clinically,it is found that FC patients are often accompanied with anxiety and depression,and the brain-gut axis plays an important role in the comorbidity.Therefore,based on the above facts,this paper aims to discuss the pathogenesis and treatment of FC associated with emotional disorders from the aspects of neurogastroenterology,brain-gut peptides,gut microbiome,hypothalamic-pituitary-adrenal axis(HPA axis) and traditional Chinese medicine treatment,and also to provide more scientific evidences for the study of the treatment of the comorbidity.