To explore the mechanism of Zingiberis Rhizoma Recens in the detoxification of Pinelliae Rhizoma based on molecular docking and data mining.Methods:The chemical ingredients of Zingiberis Rhizoma Recens were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The targets related to Zingiberis Rhizoma Recens were predicted from SwissTargetPrediction.Molecular docking was carried out after homologous modeling of agglutinin from Pinelliae Rhizoma by Swiss-model.Targets related to inflammation were screened out from DisGeNET,and the targets of Zingiberis Rhizoma Recens against inflammation were obtained by gene mapping.The protein-protein interaction(PPI) network of Zingiberis Rhizoma Recens in the treatment of inflammation was delineated by String,and the key genes were screened out.Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses were performed on target genes.Results:Five types of active compounds of Zingiberis Rhizoma Recens had strong binding force with agglutinin from Pinelliae Rhizoma.There were 49 targets of Zingiberis Rhizoma Recens in the treatment of inflammation,and 15 were key ones,including MMP9,HSP90AA1,PPARG,RELA,APP,ICAM1,MMP2,and mTOR.As revealed by GO and KEGG enrichment analyses,49 target genes were involved in biological processes such as acute inflammatory response,regulation of inflammatory response,inflammatory mediator production,T cell activation,and lymphocyte migration,and mainly enriched in the signaling pathways related to Th17 cell differentiation.Conclusion:Zingiberis Rhizoma Recens can inhibit the toxicity produced by Pinelliae Rhizoma by reducing inflammatory responses.