To explore the clinical efficacy of acupuncture and bloodletting combined with Xuefu Zhuyu Decoction in the treatment of lower extremity varicose veins.Methods:Sixty-five patients hospitalized for varicose veins of lower extremities in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2019 to December 2019 were enrolled and divided into a control group(n=32) and an observation group(n=33).The patients in the control group were treated by compression socks,and those in the observation group were treated by acupuncture and bloodletting combined with Xuefu Zhuyu Decoction.The lower extremity veins and quality of life of patients in the two groups were compared before treatment,one month,and two months after treatment by the venous clinical severity score and quality of life questionnaire.The changes in blood rheology-related indexes and serum immunoinflammatory mediators of patients in the two groups were observed and analyzed.Additionally,clinical efficacies of the two groups were compared.Results:The venous clinical severity scores of patients in both groups decreased after one month and two months of treatment,and the observation group was superior to the control group in the improvement of varicose veins at the same time point after treatment(P<0.05).The quality of life scores of patients in both groups increased after one month and two months of treatment,and the observation group was higher than the control group(P<0.05).After treatment,blood rheology-related indexes in the two groups were prone to be restored,and the indexes in the observation group were lower than those in the control group P<0.05).After treatment,serum immunoinflammatory response-related indexes in the two groups were lower than those before treatment,and the decrease in the observation group was less significant than the control group(P<0.05 or P<0.01).After treatment,the effective rate of the observation group was 93.94%,higher than 75% in the control group(P<0.05).Conclusion:Acupuncture and bloodletting combined with Xuefu Zhuyu Decoction have a reliable curative effect on varicose veins of lower extremities,which are worthy of promotion.