To analyze the demographic distribution,hospitalization characteristics,combined diseases,and medication regularity of inpatients with ischemic stroke with medical big data.Methods:The information of inpatients with ischemic stroke in the Hospital Information System(HIS) of tertiary grade A general hospitals in nine provinces and cities of China was collected.The demographic information,admissions and discharges,combined diseases,and medication information of patients were analyzed by frequency statistics and association rule.Results:Among the 39 777 patients with ischemic stroke,the median age was 68 years,and 12 420 cases(40.31%) were aged 60-74 years.The male/female ratio was 1.78:1.A total of 6 940 cases(18.58%) were in critical conditions at admission.There were 14 477 cases(36.40%) hospitalized for 15-28 days,and the patients were admitted mainly in Summer Solstice and Cold Dew.A total of 31 176 cases(78.38%) were hospitalized mainly due to acute cerebral infarction,and 701 cases(74.97%) were diagnosed with stroke due to phlegm blocking collaterals,and 101 cases(11.76%) with stroke due to qi deficiency and blood stasis.The top 3 combined diseases were hypertension(n=21 938,55.15%),diabetes(n=8 287,20.83%),and coronary heart disease(n=7 921,19.91%).Aspirin ranked first in the use of western medicine,with 20 924 cases involved(52.60%),and Shuxuetong Injection ranked first in the use of Chinese patent medicine,with 9 015 cases involved(22.66%).The blood-activating and stasis-resolving drugs and antiplatelet drugs were used in combination by 54.63% of patients.Conclusion:The inpatients with ischemic stroke were mainly aged 60-89 years and dominated by males.The onset of the disease may be related to solar terms.The main combined diseases were hypertension,diabetes,and coronary heart disease.Aspirin and Shuxuetong Injection were the most commonly used Chinese and western medicines,and Chinese patent medicines for promoting blood circulation and removing blood stasis were often used in combination with antiplatelet drugs.