To screen the potential active components，core targets，and signaling pathways of Pinelliae Rhizoma-Pogostemonis Herba for the treatment of Coronavirus Disease 2019(COVID-19) based on network pharmacology.Methods:The active components and targets of Pinelliae Rhizoma-Pogostemonis Herba were screened out by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，and the key targets were obtained by mutual mapping with COVID-19 gene sets in GeneCards and NCBI.Meanwhile，the key target interaction network was constructed by STRING and Cytoscape 3.6.1.Enrichment analysis of Gene Ontology(GO)-biological process(BP) and KEGG pathways was performed using DAVID，which was supported by molecular docking evidence.Results:There were 24 active components and 45 key targets of Pinelliae Rhizoma-Pogostemonis Herba，443 entries of biological processes，cellular components，and molecular functions，and 103 pathways.Molecular docking results showed that in Pinelliae Rhizoma-Pogostemonis Herba，β-sitosterol and quercetin showed best binding to 3CLpro and angiotensin-converting enzyme 2(ACE2)，respectively.Conclusion:The key compounds of Pinelliae Rhizoma-Pogostemonis Herba may structurally act on the invasion of the severe acute respiratory syndrome(SARS)-CoV-2 and inhibit cytokine storm from multiple components，multiple targets，and multiple pathways.Pinelliae Rhizoma-Pogostemonis Herba exert the therapeutic role by virtue of broad-spectrum antiviral，antibacterial，immunomodulatory effects and intervening in the reticular activation system.