To screen the chemical components of Biyuan Tongqiao Granules and construct an “active component-disease target” network by network pharmacology to explore the underlying mechanism of Biyuan Tongqiao Granules in the treatment of allergic rhinitis(AR).Methods:The chemical components of Biyuan Tongqiao Granules were screened out from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and DrugBank，and their targets were obtained.The AR-related targets were searched from GeneCards with the term “allergic rhinitis”.The common targets of the drug and the disease were obtained and imported into the STRING to obtain the protein-protein interaction(PPI) network which was plotted by Cytoscape 3.7.2.Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses were performed using clusterProfiler.Quercetin，apigenin，and kaempferol with abundant binding sites in drug network molecules underwent molecular docking with PTGS1，PTGS2，and serum factor IgE antibodies closely related to AR through AutoDock.Results:As revealed by network pharmacology，the potential active components of Biyuan Tongqiao Granules in the treatment of AR were quercetin，apigenin，kaempferol，ursolic acid，and rosmarinic acid，which regulated signaling pathways such as MAPK，HIF-1，NF-κB，and cAMP by mediating PTGS2，PTGS1，CHRM2，ADRB2，NOS2，and other targets，thereby exerting the anti-inflammatory effect.Molecular docking results showed that the key components had good affinity with PTGS1，PTGS2，and IgE antibodies.Conclusion:Based on network pharmacology and molecular docking technology，this study revealed that Biyuan Tongqiao Granules regulated AR through multiple components，multiple targets，and multiple systems，and provide a basis for clinical drug treatment.