Dampness and heat syndrome in traditional Chinese medicine(TCM) is the compound syndrome，most common and difficult to treat，but its etiology，pathogenesis，connotation and treatment strategies are still unclear.Through literature and clinical evidence，the traditional cognition of damp-heat syndrome，etiology and pathogenesis evolution law，syndrome formation elements and treatment strategies are discussed.We believe that the different causes of damp-heat syndrome have different damp-heat biases.Damp-heating and dampness-changing heat after heat are the main pathogenesis，the chronic inflammation state that is difficult to relieve itself and the secondary inflammation-immune-water metabolism disorder are the damp-heat syndrome.The treatment strategy of damp-heat syndrome should be formulated in consideration of the etiology，physical fitness，current symptoms and overall prognosis.