To explore the efficacy of Xiaojin Capsules combined with Selenium Yeast Capsules on Hashimoto's thyroiditis(HT) with abnormal thyroid function.Methods:A total of 180 HT patients who were treated in The First Affiliated Hospital of Henan University and Henan Provincial People's Hospital from December 2020 to December 2021 were randomized into the observation group(n=120) and the control group(n=60) according to the visiting time.The observation group was treated with Xiaojin Capsules(oral，5 capsules each time，twice a day，12 weeks) and Selenium Yeast Capsules(oral，1 capsule each time，twice a day，12 weeks)，and the control with only Selenium Yeast Capsules(oral，1 capsule each time，twice a day，12 weeks).Results:The levels of thyroid peroxidase antibody(TPO-Ab)，thyroglobulin antibody(TGAb)，free triiodothyroinine(FT3)，free thyroxine(FT4)，and thyroid stimulating hormone(TSH) in the observation group were different from those in the control group(P<0.05).Thyroid diameters showed difference between the two groups before，during and after treatment(P<0.05).The total effective rate was 82.5%(99/120) in the observation group，higher than the 56.67%(34/60) in the control group(P<0.05).Specifically，the cure rate was 22.50% in observation group，as compared with the 3.33% in control group(P<0.01).The ineffective rate was 17.50% in the observation group，lower than the 40.00% in the control group(P<0.01).The remarkably effective rate was higher in the observation group(40.83%) than in the control group(31.67%)(P<0.05).The effective rate was 19.1% in the observation group and 21.67% in the control group(P>0.05).Conclusion:Xiaojin Capsules combined with Selenium Yeast Capsules can eliminate or alleviate clinical symptoms and signs，significantly reduce serum levels of TPO-AB and TGAb，restore thyroid function，and improve thyroid morphology and structure in the treatment of HT，showing clinical efficacy is satisfactory.