Guided by the theory of liver governing the free flow of qi and regulating emotions，this study concentrated on the fluctuations of allopregnanolone and the changes in the sensitivity of γ-aminobutyric acid A receptor(GABAAR) mediated by allopregnanolone based on the research progress from the typical emotional disorder premenstrual dysphoric disorder to explore the micromechanism of the liver in failing to act freely.There is a relationship between the pathogenesis of emotional disorders and the particular emotion-regulating function of allopregnanolone，and there are variations in allopregnanolone sensitivity among those with liver dysfunction.One of the micromechanisms of emotional disorders brought on by liver dysfunction is premenstrual dysphoric disorder，and allopregnanolone mediates the sensitivity of GABAAR to alter this etiology.A modification in the body's capacity to react to variations in allopregnanolone levels is known as allopregnanolone-mediated GABAAR sensitivity.