Chronic migraine usually progresses from migraine，which is manifested by more than 15 days of headache per month and a high incidence of chronic comorbidities such as anxiety and depression.Chronic migraine has high disability，which seriously damages the quality of life of patients.Recently，the incidence rate of chronic migraine is gradually increasing，but its pathophysiological mechanism is still unclear，which hinders the research on clinical prophylactic treatment and further mechanisms.The research on the underlying pathophysiological mechanism of chronic migraine may play a positive guiding role in clinical treatment.This paper reviewed the progress mechanism of chronic migraine from the aspects of atypical pain management，central sensitization，cortical euphoria，and brain plasticity，and discussed the potential mechanisms of acupuncture in the treatment of chronic migraine，hoping to provide references for the prophylactic treatment of chronic migraine and the prevention of the chronic progress of migraine.