Chronic migraine is one of the most prevalent and disabling neurogenic inflammatory diseases in the world，severely impacting the quality of life of patients.However，its mechanism is still unclear.Recent studies suggest that the astrocyte-microglia crosstalk is observed in central inflammatory diseases，which is a new target for the elucidation of the pathogenesis and therapeutic mechanisms.Previous studies initially found that the mechanism of acupuncture in the treatment of chronic migraine was closely related to its regulation of astrocytes and microglia.Therefore，based on astrocyte-microglia crosstalk，the latest research frontier of neuroinflammatory diseases，this paper explored the possibility of introducing it into the mechanism study of acupuncture in the treatment of chronic migraine，thereby providing new scientific ideas for the treatment of chronic migraine with acupuncture.