To evaluate the efficacy and safety of Yiqi Huoxue Formulas systematically in the treatment of microvascular angina.Methods:CNKI，CSPD，CCD，PubMed，Embase，and Cochrane Library were searched to collect the research articles on the treatment of microvascular angina with Yiqi Huoxue Formulas from database inception to October 1，2020.After screening and extraction of effective data，RevMan5.3 software was used for Meta-analysis of the relevant indicators in the included articles.Results:Twenty-five randomized controlled trials(RCTs)，all in Chinese，were enrolled，with 1 664 patients involved.The results of Meta-analysis showed that the experimental group was superior to the control group in terms of clinical efficacy(RR=1.23，95%CI 1.16 to 1.29，P<0.000 01)，electrocardiogram efficacy(RR=1.31，95%CI 1.17 to 1.46，P<0.000 01)，the occurrence of angina attack(SMD=-1.68，95%CI -2.55 to -0.81，P＝0.000 2)，duration of angina attack(MD=-2.37，95%CI -3.44 to -1.31，P<0.000 1)，total exercise time(SMD=1.36，95%CI 0.55 to 2.18，P＝0.001)，ET-1(SMD=-1.54，95%CI -1.92 to -1.16，P<0.000 01)，NO(SMD=1.76，95%CI 1.08 to 2.44，P<0.000 01)，and hs-CRP(SMD=-1.23，95%CI -2.22 to -0.24，P＝0.01).The differences between the two groups were statistically significant(P<0.05).Conclusion:The combination of Yiqi Huoxue Formulas is safe and superior to conventional western medicine in the treatment of microvascular angina.