To determine the chemical composition of Phyllanthus emblica pomace and optimize the extraction process and formulation prescription of no-wash gel，thereby developing P.emblica pomace no-wash gel.Methods:High-performance liquid chromatography(HPLC) method was used to determine the content of gallic acid，corilagin，chebulagic acid，and ellagic acid in P.emblica pomace and Phyllanthi Fructus.The main antibacterial active components in P.emblica pomace were screened out by the inhibition zone.The single-factor experimental design was used to optimize the extraction process of P.emblica pomace.Taking sensory evaluation and physical and chemical properties of no-wash gel as indicators，the Box-Behnken response surface methodology was used to optimize the formulation of the bacteriostatic no-wash gel of P.emblica pomace.Results:The components of P.emblica pomace and Phyllanthi Fructus were basically the same.The content of gallic acid，corilagin，chebulagic acid，and ellagic acid in P.emblica pomace was about 21.99%～67.63%，0.52%～4.79%，7.38%～8.79%，and 10.15%～16.10% of the content in Phyllanthi Fructus.The minimal inhibitory concentration(MIC) of chebulagic acid，corilagin，and gallic acid against Monilia albican，Escherichia coli，and Staphylococcus aureus were all lower than 10 μg/mL，while the MIC of ellagic acid was 16.38～32.75 μg/mL.Taking gallic acid，corilagin，and chebulagic acid as evaluation indicators，the optimal extraction process was adding 10 times the volume of 70% ethanol in P.emblica pomace，refluxing for 2 h，and extracting it once.The optimized formula obtained by the Box-Behnken response surface method was 30% of raffinate residue extract，0.4% of carbomer U20，3% of glycerol，4% of 95% ethanol，triethanolamine with a pH value of 5～6，and purified water.Conclusion:P.emblica pomace has good development value，and the preparation process of no-wash gel is feasible，which provides a technical path for the comprehensive development and utilization of solid waste of Chinese medicine.