Burning mouth syndrome is an oral mucosal disease with burning pain as the main manifestation and no obvious lesions，and its patients are often accompanied by anxiety，depression and other negative emotions.According to clinical experience，Professor Xu Fengquan summed up the pathogenesis characteristics of the disease that patients present gallbladder depression transforming into fire and turbid phlegm blocking collaterals.On this basis，WenDan Jieyu Huatan Formula was innovatively proposed，and its theoretical basis for treatment of burning mouth syndrome was also discussed by combing the pathological characteristics of the disease and modern mechanism of the method，combined with clinical medical records and common drug pairs used by Professor Xu.This paper aimed to provide strong theoretical support for clinical treatment of burning mouth syndrome and improve the clinical curative effect.