To study the therapeutic effects of Codonopsis Radix on chronic obstructive pulmonary disease(COPD) and its effect on inflammatory factors in the mouse model of COPD.Methods:The mouse model of COPD was replicated by the nasal drip of COPD-establishing liquid,and the changes in behavior,lung wet/dry weight ratio,and inflammatory factors ［interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),and nuclear factor kappa B(NF-κB)］ in the mouse model of COPD were observed after trial drug intervention.The therapeutic effects of Codonopsis Radix on mice with COPD and its mechanism were studied.Results:The 10.4 g/kg,5.2 g/kg,and 2.6 g/kg Codonopsis Radix significantly improved the COPD behaviors of mice such as scratching nose,scratching,and abnormal respiration,reduced lung wet/dry weight ratio and the content of IL-1β,IL-6,and IL-8,and down-regulated the expression levels of NF-κB in the lung tissue(P<0.05,P<0.01).Conclusion:Codonopsis Radix has therapeutic effects on COPD,and one of its mechanisms is to down-regulate the expression of inflammatory factors and alleviate airway inflammation.