The basic pathogenesis of chronic immune thrombocytopenia in children is the deficiency in origin and excess in superficiality.The deficiency of qi and yin is the origin of the disease,and heat,toxin,and blood stasis are the superficiality of the disease.As pathogenic factors and pathological products,they are causal factors and run through the whole pathological process.In light of the etiology and pathogenesis of chronic immune thrombocytopenia in children,the unique treatment concept and ideas of ZHANG Zhongjing of formulating complicated prescriptions were applied based on syndrome differentiation following the principles of strengthening healthy qi and tonifying deficiency,clearing heat and removing toxins,promoting blood circulation and removing blood stasis,and significant efficacy could be achieved.