To explore the efficacy and safety of Huatuo Zaizao Pill in the treatment of ischemic stroke in Slavic population,and to provide evidence for the treatment of ischemic stroke with Huatuo Zaizao Pill in Eastern Europe.Methods:In this prospective randomized controlled study,44 patients with convalescent ischemic stroke at the 11th Clinical Hospital in Minsk,Belarus,were randomly divided into a control group and an experimental group.The control group was given conventional treatment,while the experimental group was given Huatuo Zaizao Pill,8 grams each time,twice a day,in addition to the treatment of the control group.After 3 months of treatment,comparison was made between two groups with regard to the National Institutes of Health Stroke Scale(NIHSS) score,Barthel index(BI) score,modified Rankin scale(mRS) score,blood routine,urine routine,glycated hemoglobin and coagulation factors ［prothrombin time(PT),activated partial thromboplastintime(APTT),thrombin time(TT),thrombin time(TT)］ to evaluate the efficacy and safety of clinical application of Huatuo Zaizao Pill.Results:No significant differences were observed regarding the demographic characteristics and in NIHSS score,BI score and mRS score between the two groups at 1 and 3 months after treatment(all P>0.05).Compared with the control group,the experimental group underwent a remarkable decrease in the NIHSS upper limb exercise score at 1 and 3 months after treatment(P<0.05).There was no significant difference in blood routine,urine routine,glycosylated hemoglobin and coagulation factors between the two groups at 1 and 3 months after treatment(P>0.05).Conclusion:The study suggested that Huatuo Zaizao Pill could significantly improve motor function of the upper limbs of the patients,with good clinical safety.The efficacy and safety of Huatuo Zaizao Pill in the treatment of ischemic stroke in Slavic population have been verified,which provided research evidence for the application of the prescription in patients with ischemic stroke in Eastern Europe.