Xinkeshu,a major variety of Chinese patent medicine for the treatment of coronary heart disease in the clinic,is composed of Salviae Miltiorrhizae Radix et Rhizoma,Puerariae Lobatae Radix,Notoginseng Radix et Rhizoma,Crataegi Fructus,and Aucklandiae Radix.It has the functions of activating blood circulation,removing blood stasis,promoting qi,and relieving pain.It is clinically used in the treatment of coronary heart disease such as unstable angina pectoris,with accurate curative effect.The chemical constituents of Xinkeshu are salvianolic phenolic acids of Salvia miltiorrhiza,flavonoids of Pueraria lobata,saponins of Panax notoginseng,flavonoids and triterpenoids of Crataegus pinnatifida Bunge,and sesquiterpenoids of Aucklandia lappa.The pharmacological effects mainly involve anti-myocardial ischemia,anti-ischemia-reperfusion injury,improvement of endothelial function,anti-anxiety/depression,anti-inflammation,anti-platelet aggregation,etc.In this paper,the Chinese and foreign studies were retrieved to summarize and analyze the chemical constituents,pharmacological effects,and mechanisms of Xinkeshu,to provide references for its quality control improvement,secondary development,and clinical rational use.