The causes of insomnia are complicated.Professor Wang Qingguo studied the academic thought of Zhang Zhongjing and is good at treating insomnia by regulating the pivot in view of the nutrient-defense disharmony and yang failing to enter yin.The pivot is closely related to the function of the liver.For patients with depression caused by liver failing to govern the free flow of qi and disorder of qi movement，or patients with deficiency caused by liver failing to store blood and spirit failing to be nourished，the “harmony” method should be applied to achieve yin-yang harmony，nutrient-defense harmony，and heart spirit harmony.As a result，the depression is mainly alleviated and deficiency can also be relieved.Chaihujialonggumuli Decoction can be modified according to the syndrome for the treatment of insomnia，which is remarkably effective.