Asthenopia has developed into a global health problem.In clinics，attention is paid to its prevention and health care，and symptoms and signs can be relieved by eye use adjustment，appropriate substances，physical intervention，and rest.At present，asthenopia is mainly diagnosed by subjective symptoms，and there is no objective index that accurately reflects the state，resulting in adequate methods and mechanisms for experiments and clinical evaluation.The establishment of an animal model of asthenopia and a traditional Chinese medicine(TCM) syndrome model related to asthenopia based on its understanding and diagnosis and treatment characteristics in TCM，helps further explain the occurrence and development mechanism of asthenopia and comprehensively explore the advantages of TCM for the prevention and healthcare of the disease.This paper summarized the research status of animal models of asthenopia，and proposed the construction principles and strategies.In addition，by reference to TCM clinical literature，it was found the TCM syndromes of asthenopia patients were mainly liver-kidney yin deficiency，liver depression and qi stagnation and liver blood deficiency，and the construction principles and strategies of the TCM syndrome model related to asthenopia were further proposed.This paper was expected to provide ideas for the research and development of TCM products for relieving asthenopia，and provide guidance for the syndrome differentiation-based health care and precise application of asthenopia.