To explore the medication characteristics and formulation rules of traditional Chinese medicine(TCM) in the treatment of prostate cancer based on various databases in the past 10 years.Methods:Databases，such as Wanfang Data，VIP，CNKI，and Pubmed were searched from January 2011 to December 2020 for TCM prescriptions or preparations for the treatment of prostate cancer.Medication characteristics and formulation rules of TCM prescriptions were analyzed based on Traditional Chinese Medicine Inheritance Support System V2.5(TCMISS V2.5).Results:Sixty-one prescriptions were included，involving 149 TCM drugs.There were 15 TCM drugs with frequency≥10 times，and the top 5 TCM drugs were Astragali Radix(38)，Rehmanniae Radix Praeparata(30)，Poria(25)，Hedyotidis Diffusae Herba(22)，and Psoraleae Fructus(21).The statistical results of TCM drugs classification showed that deficiency-tonifying and heat-clearing drugs were used most frequently(58.35%)，followed by urination-promoting and dampness-draining drugs(11.45%) and blood-activating and stasis-resolving drugs(10.97%).In terms of qi，warm drugs were used most frequently(40.10%)，and in terms of flavor，sweet drugs were used most frequently(40.35%).In terms of meridian tropism，the majority of drugs mainly acted on spleen，kidney，liver，lung，and stomach meridians，accounting for 77.24%.When the degree of support was set to 12，14 common drug pairs were obtained based on association rules，involving 10 TCM drugs，and the top 5 drug pairs included Curcumae Longae Rhizoma-Astragali Radix(17)，Astragali Radix-Psoraleae Fructus(17)，Astragali Radix-Poria(16)，Codonopsis Radix-Astragali Radix(16)，and Hedyotidis Diffusae Herba-Scutellariae Barbatae Herba(16).Correlation analysis of drug pairs was conducted based on the entropy hierarchical clustering method with correlation degree of 5 and penalty degree of 2，and correlation coefficient of 0.06 was selected for cluster analysis.Finally，23 drug pairs were obtained.The core combination analysis based on complex system entropy clustering indicated that eight core combinations of three TCM drugs and four core combinations of four TCM drugs were evolved.At the same time，two new combinations of drugs were extracted，and two new prescriptions were obtained.Conclusion:The TCM treatment of prostate cancer should follow the principles of strengthening the body and eliminating pathogens.The clinical treatment should pay attention to the application of qi-benefiting and healthy qi-reinforcing TCM drugs and the combination of disease and syndrome，treatment based on syndrome differentiation，and other approaches should be employed for intervention.