Professor Hua Baojin has been engaged in the prevention and treatment of tumor recurrence and metastasis by traditional Chinese medicine(TCM) for decades.He proposed the theory of regulating qi and removing toxin based on the theory of ascending and descending qi movement as well as the development characteristics of modern medicine and applied it in clinical practice.This paper summarized and analyzed Professor Hua's experience in treating small cell lung cancer(SCLC) with brain metastasis by regulating qi and removing toxin.It discussed the current treatment situation of SCLC with brain metastasis and explored the positive effect of TCM based on the theory of regulating qi and removing toxin in relieving clinical symptoms of the disease，improving the quality of life of patients，and delaying disease progression from the perspectives of etiology and pathogenesis，academic thought，and medication characteristics with clinical medical records attached.This paper was expected to facilitate the TCM treatment of SCLC with brain metastasis.