This study used computer network pharmacology and molecular docking technology to predict the potential molecular mechanism of Cortex Moutan and Salviae Miltiorrhizae in the treatment of psoriasis.Methods:Firstly，the targets of diseases and ingredients screened by TCMSP，GeneCards and OMIM platforms were intersected.After obtaining the intersection targets，GO and KEGG enrichment analyses were performed.Cytoscape 3.8.2 was applied to construct the PPI network and “ingredient-target-pathway” network diagram.Finally，the molecular docking test was performed using Schrdinger Maestro 11.8.Results:A total of 58 active ingredients and 95 targets of Cortex Moutan and Salviae Miltiorrhizae in the treatment of psoriasis were obtained.They mainly involved in such biological processes as lipopolysaccharide response，inflammation reaction，nutrient levels，and oxidative stress，and regulated such signaling pathways as IL-17，TNF，Th17 cell differentiation，and HIF-1.The results of molecular docking technology confirmed a high affinity between main active ingredients and core targets.Conclusion:Cortex Moutan-Salviae Miltiorrhizae may be used to treat psoriasis through multiple components，multiple targets，and multiple pathways.