To explore the intervention effect of the optimal compatibility(SABP) of the water-soluble active ingredients of Salvia miltiorrhiza on the proliferation of ApoE-/- mouse vascular adventitia fibroblasts(VAFs) in vivo and in vitro.Methods:The VAFs of primarily cultured C57BL/6J mice and ApoE-/- mice were given normal medium，SABP and rosuvastatin(RC) in vitro.ApoE-/- mice were divided into the model group，SABP group and RC group，and C57BL/6 mice were used as the normal control group.After primary culture and administration，the proliferation of VAFs was detected by CCK-8 method.Results:In vitro and in vivo results showed that SABP and RC significantly inhibited the proliferation of VAFs in ApoE-/- mice，of which SABP had a more significant effect.Conclusion:SABP can significantly inhibit the proliferation of VAFs in ApoE-/- mice，which is expected to improve vascular remodeling and become a substitute drug for cardiovascular diseases.