To observe the effects of Prof.WANG Qi's self-prepared Huatan Qushi Formula(Yizhi Granules) and Yiqi Jianyun Formula(Fuyuan Granules) on foam cell lipids，and to explore the mechanism of autophagy.Methods:RAW264.7 cells were cultured，and a foam cell model was constructed with oxidized low-density lipoprotein(ox-LDL).Cell viability was determined by cell titer-blue method，the lipid content in cells was detected by oil red O staining method，CD36 and LC3 protein expressions were detected by Western Blot method，and the effects of the two formulas on foam cell autophagy were further studied using autophagy protein chips.Results:The Oil red O staining results showed that the lipid content in cells in the ox-LDL model group increased，suggesting that foam cell modeling was successful.After the intervention with the two formulas，the lipid content in cells decreased.The Western blot results showed that the CD36 expression increased after the intervention with the two formulas，and the LC3Ⅱ/LC3Ⅰ expression increased in the Huatan Qushi Formula(50 ng/μL) group and the Yiqi Jianyun Formula(50 ng/μL，100 ng/μL) group.The results of autophagy chips showed that compared with the control group，the P62 expression in the ox-LDL model group increased.Compared with the ox-LDL model group，the P62 expression decreased and the ATG10 expression was up-regulated in the Huatan Qushi Formula group，while the ATG10，ATG12，and ATG4A expression were up-regulated in the Yiqi Jianyun Formula group.Conclusion:Both formulas can reduce the lipid content in foam cells，and the possible mechanism is that they promote lipid metabolism and reduce the formation of foam cells by enhancing the autophagy of macrophages.