To evaluate the clinical efficacy of heat-clearing and detoxifying TCM injections in the treatment of acute ischemic stroke by network Meta-analysis.Methods:Chinese and English databases，including the Chinese Journal Full-text Database(CJFD)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，China Biology Medicine disc(CBM)，PubMed，Web of Science，and Cochrane Library，were searched from the date of construction to November 2020.Two researchers screened the literature and extracted the data back to back，evaluated the quality using the Cochrane bias risk assessment tool，and analyzed the data using Review Manager5.4.1，Stata15.1，ITC and gemtc package of R software.Results:A total of 40 studies were finally included.The results showed that 1) in the improvement of the total clinical effective rate，Kudiezi Injection(OR=5.02，95%CI was 3.26 to 7.74，P<0.000 01)，Qingkailing Injection(OR=4.05，95%CI was 1.98 to 8.28，P<0.000 01)，and Xingnaojing Injection(OR=3.49，95%CI was 2.73 to 4.47，P<0.000 01) combined with Western medicine respectively were superior to Western medicine alone，and Kudiezi Injection combined with Western medicine was the best; 2) in the improvement of neurological deficits，Kudiezi Injection(MD=-3.24，95%CI was -4.52 to -1.97，P<0.000 01)，Qingkailing Injection(MD=-4.04，95%CI was -7.32 to -0.76，P=0.02)，Xingnaojing Injection(MD=-3.86，95%CI was -4.66 to -3.05，P<0.000 01) combined with Western medicine respectively were also superior to Western medicine alone.Xingnaojing Injection combined with Western medicine showed better effect; 3) in the improvement of activities of daily living，Kudiezi Injection(MD=11.66，95%CI was 5.74 to 17.59，P=0.000) and Xingnaojing Injection(MD=10.88，95%CI was 4.94 to 16.83，P=0.000 3) combined with Western medicine respectively were superior to Western medicine，and there was no statistical difference between them(P=0.89>0.05).Conclusion:Heat-clearing and detoxifying TCM injections combined with Western medicine can improve the total clinical effective rate of patients with acute ischemic stroke，and their neurological function and activities of daily living，but the orders of efficacy are different，which may be related to the low quality of the included studies.In the future，high-quality randomized controlled trials are still needed for further verification.