To explore the risk factors of endpoint events in patients with diabetic kidney disease(DKD) and to analyze the protective effect of Bushen-Tongluo Method.Methods:A retrospective cohort study was conducted to collect the data of DKD patients who were regularly followed up for≥3 months and had a baseline estimated glomerular filtration rate(eGFR) of 15~90 mL/min·1.73 m2 in the Department of Nephrology and specialized outpatient departments of Beijing Hospital of Traditional Chinese Medicine，Capital Medical University from January 2015 to December 2019.Entering the phase 5 of chronic kidney disease(CKD)，renal replacement therapy or death were the primary endpoint events，and progression of CKD was the secondary endpoint event.Results:A total of 123 patients with DKD were followed up for a median of 12(3~48) months，and 81 patients(65.9%) entered the endpoint events.Multivariate Cox analysis showed that low baseline eGFR，heart failure，and rhabdomyolysis were risk factors for endpoint events，while Bushen-Tongluo Method was the protective factor.The incidence of endpoint events in the Bushen-Tongluo group was significantly lower than non-Bushen-Tongluo group(P<0.05)，which were 61.1% and 82.1%，respectively.The endpoint events risk in the Bushen-Tongluo group was 0.530(95%CI was 0.305 to 0.921，P<0.05).Conclusion:Low baseline eGFR，heart failure and rhabdomyolysis are the risk factors for endpoint events in DKD patients，while Bushen-Tongluo Method can reduce the risk of endpoint events in DKD patients.