To analyze the therapeutic effect of Shouhui Tongbian Capsules on constipation in patients with primary liver cancer after drug-loaded microsphere intervention.Methods:Patients with primary liver cancer admitted to Linyi Cancer Hospital from July 2019 to August 2021 were retrospectively selected，among whom 92 patients with constipation after drug-loaded microsphere intervention were studied.They were divided into two groups based on the laxative drugs used，with those who took Tongbianling Capsules as the control group，and those who took Shouhui Tongbian Capsules as the observational group.The clinical efficacy for traditional Chinese medicine(TCM) symptoms，efficacy for constipation symptoms，and the occurrence of adverse reactions were used as specific evaluation indicators.Results:After treatment，the clinical efficacy for TCM symptoms and constipation symptoms in the two groups were improved，and the observational group was better than the control group，with significant differences between them(P<0.05); the incidence of adverse reactions in the observational group was lower than that in the control group，with significant differences between them(P<0.05).Conclusion:Patients with primary liver cancer are prone to constipation after drug-loaded microsphere intervention.Shouhui Tongbian Capsules can better improve the symptoms of constipation，and have more significant effect than conventional drugs.Thus，it can be promoted in clinical practice.