The dual-regulation effect of traditional Chinese medicine(TCM) embodies the integrity and specificity of TCM，and the holism and syndrome differentiation.Based on the Q-marker principle，the active ingredients and pharmacological effect of Panax ginseng，Panax quinquefolius and Panax notoginseng were studied to analyze the material basis of their dual-regulation effect，aiming to explore the scientific connotation of the dual-regulation effect of the three traditional Chinese medicines and provide theoretical support for the accurate control of q-markers of dual-regulation effect.