Sleep is an essential biological process，which plays a key role in human metabolic regulation.The reduction of sleep time is related to such diseases as diabetes，obesity，metabolic syndrome and cardiovascular diseases.There are many kinds of metabolic changes caused by sleep disorders，most of which are related to lipids or fatty acid products.In recent years，the relationship between sleep and lipid metabolism has gradually received clinical attention.This paper reviews the research progress of the relationship between sleep disorders and lipid metabolism，as well as the possible mechanism of abnormal lipid metabolism caused by sleep disorders，in order to provide ideas for the diagnosis and treatment of sleep disorders and metabolic diseases.