To observe the curative effect of pure traditional Chinese medicine(TCM) and integrated traditional Chinese and western medicine(TCM+western medicine) in the treatment of advanced colorectal cancer(CRC).Methods:The data of patients with advanced CRC receiving TCM treatment in the Department of Oncology，Guang'anmen Hospital，China Academy of Chinese Medical Sciences from January 1，2000 to December 31，2011 were reviewed.The general situation，treatment plans，short-term and long-term effects，and changes in health economic indicators of patients treated with TCM and TCM+western medicine were analyzed and compared.Results:The total effective rate of the TCM+western medicine group was 41.46% higher than 6.67% of the TCM group.The tumor control rate of the TCM+western medicine group was 76.42% higher than 62.22% of the TCM group，while the stability rate(34.96%) was lower than that(55.56%) of the TCM group.The improvement rate(33.61%) and stability rate(51.64%) of Kanofsky performance score(KPS) in the TCM+western medicine group were significantly higher than those(22.09% and 41.86%) in the TCM group.Additionally，the TCM+western medicine group had increased improvement rate(37.50%) and stability rate(47.12%) of body mass as compared with those(15.52% and 45.76%) in the TCM group.In terms of the median overall survival(OS)，the TCM+western medicine group was 24 months，while the TCM group was 19 months(P>0.05).In terms of the median disease to progression(TTP)，the TCM+western medicine group(10 months) was superior to the TCM group(6 months)(P<0.05).The TCM group had shorter average length of hospitalization(P<0.05)，but the TCM+western medicine had lower cost-effectiveness ratio.Conclusion:TCM+western medicine has higher total effective rate and tumor control rate and longer TTP.However，pure TCM has more treatment methods，higher tumor stability rate，and shorter length of hospitalization.The survival time is the same.