Substances that can be used as both food and medicine are abbreviated as edible and medicinal substances.They are often applied to the prevention and treatment of diseases or healthcare in traditional Chinese medicine.With the rapid development of big health industry in China，edible and medicinal substances have become a hot topic in the health field.In recent years，with the rising variety of edible and medicinal substances，the types and application of innovated products have increased，and the safety of the new proposed new edible and medicinal substances has become the focus of attention.This article summarized the edible and medicinal values，safety，adverse reactions，provincial risk monitoring content and programs of nine pilot edible and medicinal substances listed by the National Health Commission of the People's Republic of China and the State Administration for Market Regulation.It aimed to provide reference for the safety risk monitoring of the nine pilot edible and medicinal substances，and facilitated the rational application and resource development of edible and medicinal substances.