To visually analyze the related literature on the application of Sijunzi Decoction in China in the past decade by CiteSpace to discuss the application of Sijunzi Decoction.Methods:The research articles on the application of Sijunzi Decoction were retrieved from CNKI from January 1，2011，to December 31，2020，and the knowledge map in this field was plotted by using CiteSpace software.Co-occurrence analysis，clustering analysis，timeline analysis，and burst analysis were performed on the keywords in the articles.Results:A total of 1 378 articles related to the application of Sijunzi Decoction were obtained through preliminary retrieval，and after the secondary screening，1 129 articles were included，with the research hotspots of Sijunzi Decoction in the treatment of chronic gastritis，ulcerative colitis，and gestational diabetes mellitus.Conclusion:This study analyzed the hotspots and development trends of the research on the application of Sijunzi Decoction by knowledge mapping to provide references for future research and improve the application value of Sijunzi Decoction.