The present study reviewed the advances of traditional Chinese medicine(TCM) in the treatment of multiple sclerosis(MS) from historical evolution，etiology，pathogenesis，and treatment.The disease is located in the kidney and involves the liver，spleen，stomach，lung，heart，and other organs.Wind，cold，latent pathogen，heat，fatigue，sorrow，and sex are related to the onset of MS.At present，the TCM treatment of MS mainly focuses on tonifying the kidney，as well as the liver and spleen，and clearing heat，dispelling dampness，resolving blood stasis，and eliminating phlegm serve as auxiliary methods.Acupuncture，moxibustion，tuina，and traditional sports also show certain effects.TCM psychotherapy can also be used in MS-caused mental disorders.