Chronic hepatitis B is lingering and difficult to heal，and some patients are prone to secondary depression，which makes the condition more complicated.Based on the theory of liver storing blood and blood housing mood in emotional diseases and its pathological manifestations，this article believes that the core pathogenesis of depression secondary to chronic hepatitis B is liver blood deficiency，which causes the failure of blood in nourishing the soul and eventually causes the disharmony between the liver and the soul.In the clinical treatment of the patients with chronic hepatitis B，the Chinese medicines for nourishing liver，tonifying kidney，invigorating spleen，and tranquilizing mind can be used to prevent depression，thereby achieving prevention before disease onset and controlling development of existing disease.