To identify the chemical components of Qingli Shire Granules after water extraction，concentration，drying and granulation and determine the attribution of their medicinal flavor by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS).Methods:The determination was performed on an Agilent ZORBAX RRHD Eclipse XDB-C18 column(2.1 mm×100 mm，1.8 μm) with gradient elution of 0.1% formic acid aqueous solution and acetonitrile as mobile phase system.The sample size was 5 μL.The treated Qingli Shire Granules were detected by mass spectrometry under positive and negative ion modes.Results:Fifty-four compounds were identified from the samples by comparing with Natural Products HR-MS/MS Spectral Library 1.0 database，literature analysis，and cracking rules of mass spectrometry.Conclusion:This study provides a basis for the quality control of Qingli Shire Granules and preliminarily determines the possible pharmacodynamic substance basis of this product.