To observe the clinical effect of Gengxin Decoction on the treatment of perimenopausal insomnia with heart-kidney non-interaction syndrome.Methods:Forty cases of perimenopausal insomnia with heart-kidney non-interaction syndrome were selected from the gynecological clinic of Dongzhimen Hospital of Beijing University of Chinese Medicine from June 2019 to January 2021，including 20 cases in the experimental group treated with Gengxin Decoction Granules and 20 cases in the control group treated with zopiclone.The course of treatment in both groups was 4 weeks.The general data and basic clinical conditions of patients were collected.The changes in Pittsburgh Sleep Quality Index(PSQI) scale scores were the main efficacy indicators，and the changes in the modified Kupperman scale，Traditional Chinese Medicine(TCM) Syndrome Scale scores，and sleep latency and sleep time in sleep monitoring items were the secondary efficacy indicators.The changes in indexes in blood routine，urine routine，and biochemical test results and the occurrence of adverse reactions were used as safety indexes，the clinical treatment effect and safety indexes were evaluated before and after treatment，and the data results were sorted and analyzed by SPSS 20.0 software.Results:Gengxin Decoction and the third-generation cyclopyrrolidone hypnotic zopiclone effectively improved perimenopausal insomnia symptoms of women，prolonged patients' sleep time，and improved sleep efficiency(P>0.05).At the same time，Gengxin Decoction safely and effectively improved other perimenopausal syndrome-related symptoms，and the curative effect was significantly better than that of zopiclone(P<0.05).Conclusion:Gengxin Decoction can effectively improve women's insomnia symptoms during perimenopause，prolong sleep time，and improve sleep efficiency.At the same time，it can also relieve women's symptoms related to perimenopausal syndromes such as hot flashes，sweating，palpitation and dreaminess，five-heart fever，dizziness and tinnitus，waist and knee soreness，dry throat，and lack of saliva，with significant effects.