To reveal the medication rules of Chinese medicinal prescriptions in the treatment of pulmonary nodules based on data mining.Methods:The literature on the treatment of pulmonary nodules with Chinese medicinal prescriptions was retrieved for the building of a database of prescriptions for pulmonary nodules.SPSS 26.0 and SPSS modeler 18.0 were employed to analyze the natures，tastes，meridian tropism，frequency，association rules，systematic clustering，and complex networks of the medicines in the prescriptions.Results:A total of 122 prescriptions involving 194 Chinese medicines belonging to 19 major categories were included，and the total frequency of Chinese medicines used was 1 917.The medicine were mainly cold，warm and plain，tasted bitter，sweet，and pungent，and had tropism to the spleen(stomach)，lung(large intestine)，and liver(gallbladder) meridians.The Chinese medicines commonly used were tonifying medicines，heat-clearing medicines，phlegm-resolving medicines，stasis-resolving medicines，and qi-moving medicines.The Chinese medicines with high frequency were Glycyrrhizae Radix et Rhizoma，Fritillariae Thunbergii Bulbus，Astragali Radix，Poria，Angelicae Sinensis Radix，Atractylodis Macrocephalae Rhizoma，Pinelliae Rhizoma，Ostreae Concha，Prunellae Spica，and Chuanxiong Rhizoma.Six Chinese medicine combinations with strong associations were predicted.The cluster analysis yielded 5 groups of Chinese medicine combinations.The complex network analysis showed that the medicines were mainly used to invigorate spleen，replenish qi，nourish yin，resolve phlegm，dissipate mass，nourish and activate blood，and move qi.Conclusion:Pulmonary nodules are rooted from the qi deficiency in lung and spleen and have the syndromes of qi stagnation，phlegm coagulation，and blood stasis.The treatment should involve both lung and spleen/liver and apply the theories of cultivating earth and generating gold，nourishing qi and yin，pungent dispersing and bitter descending，and regulating qi and blood.Sijunzi Decoction，Erchen Decoction，Shashen Maidong Decocton，and Chahu Shugan Powder can be modified according to the syndromes and the treatment methods such as regulating qi to resolve phlegm，activating blood to resolve stasis，and softening hardness and dissipating mass can be employed.