To study the therapeutic and death protective effects of Gegentang Granules on the mouse model of viral pneumonia caused by infection with influenza A(H1N1) virus PR8 strain.Methods:The mouse model of viral pneumonia was established by nasal dripping with influenza A H1N1 virus(PR8 strain).The lung index and lung index inhibition rate were recorded，and the pathological changes of the bronchus and lung tissue were observed and graded by hematoxylin-eosin staining.At the same time，we established a mouse model of influenza virus PR8 strain infection by nasal dripping to observe the death of mice within 2 weeks after infection，and recorded the mortality rate，death protection rate，average survival days，and life extension rate.Results:Medium- and high-dose Gegentang Granules reduced the lung index(P<0.01) and alleviated bronchial inflammation and exudation，redness and swelling，alveolar and pulmonary interstitial inflammation，and erythrocyte extravasation caused by viral infection(P<0.01，P<0.05) compared with the model group.The mice in the model group showed a mortality rate of 90% and the average survival of 9.95 days.Compared with the model group，the three doses of Gegentang Granules reduced the mortality rate of mice，prolonged the average survival days，and improved the life extension rate of mice(P<0.01，P<0.05).Conclusion:Gegentang Granules can significantly reduce the lung index and alleviate the bronchial and local pulmonary inflammation caused by viral infection，demonstrating an obvious therapeutic effect on the pulmonary inflammation of the model mice.Moreover，it can significantly reduce the mortality，prolong the average survival days，and improve the life extension rate，protecting the infected mice from death.