To summarize the medication rules of Professor Lyu Renhe in treating chronic kidney disease(CKD) and elucidate the academic thought and clinical experience.Methods:The prescriptions used by Professor Lyu for treating CKD from January 2012 to June 2021 were selected.FangNet and PageRank algorithm were employed to analyze the natures，tastes，meridian tropism of Chinese medicines，core medicines，and medicine combinations of the prescriptions.Results:A total of 294 patients corresponding to 294 consultations were included in this study.The prescriptions involved 159 Chinese medicines with the total frequency of 2 304.The Chinese medicines used in the prescriptions were mainly plain，cold，or warm，tasted sweet or bitter，and showed tropism to liver，heart，spleen，and kidney meridians.The weight ranking showed that the core medicines were Salviae Miltiorrhizae Radix et Rhizoma，Polyporus，and Chuanxiong Rhizoma.The co-occurrence network showed that the common medicine pairs were Citri Fructus-Citri Sarcodactylis Fructus，Persicae Semen-Carthami Flos，and Paeoniaeradix Rubra-Moutan Cortex.The cluster analysis revealed nine medicine clusters，which reflected Professor Lyu's ideas of treating liver and kidney together and activating blood and promoting urination at the same time.Conclusion:PageRank algorithm was employed to analyze the medicine-medicine and symptom-medicine correlations.Professor Lyu emphasizes the combination of disease and syndrome and advocates staged treatment based on syndrome differentiation by applying medicine pairs and combinations with consideration to different symptoms and signs.Following the principle of activating blood，resolving stasis，and dissipating nodules，the treatment should consider both reinforcing healthy qi and dispelling pathogenic qi.