Liver qi stagnation can lead to the formation of qi stagnation，blood stasis，water retention，and other pathological states，and the disorder of qi，blood，and water is the core pathogenesis of liver cirrhosis.This article analyzed the targeted use of insect drugs for different stages of liver cirrhosis，such as “qi stagnation-blood stasis-qi deficiency-water retention”.The use of insect drugs in the treatment of liver cirrhosis and ascites was summarized from the following four aspects:dissipating mass，softening hardness，and breaking qi for attacking，expelling wind in collaterals，removing phlegm，resolving stasis for dredging，tonifying the liver and kidney for nourishing，and reinforcing healthy qi，resolving stasis，and excreting water for eliminating.Insect drugs can play a role in softening hardness，dispersing mass，promoting blood circulation，removing blood stasis，tonifying for consolidating the root，resolving stasis，and excreting water.These properties and special effects are particularly suitable for the pathogenesis of “long-term illness with qi stagnation”，“phlegm and blood stasis obstructing the collaterals”，“long-term illness resulting in qi deficiency”，and “blood stasis and water retention” during the course of liver cirrhosis.