Professor Xie Jingri has rich clinical experience and unique opinions in the treatment of Barrett's esophagus.By analyzing the clinical medical records and Professor Xie Jingri's medication laws，we summarized five commonly used drug pairs：Sepiae Endoconcha-processed Arcae Concha，Pogostemonis Herba-Eupatorii Herba，Angelicae Sinensis Radix-Chuanxiong Rhizoma，Jiao Sanxian(Hordei Fructus Germinatus Praeparatus，Crataegi Fructus Praeparatus，Massa Medicata Fermentata Praeparatus)-Galli Gigerii Endothelium Corneum，and Notoginseng Radix et Rhizoma-Bletillae Rhizoma.The simple compatibility of the drug pair is practical，convenient，and flexible，demonstrating a high clinical value.Referring to Professor Xie's theory of the liver and spleen，this article probed into Professor Xie's experience in treating Barrett's esophagus from four properties and five flavors，drug natures，tastes and meridian tropism，famous medical classics，and modern pharmacological research.