To observe the clinical efficacy of Zishui Qinggan Decoction combined with Remifemin Tablets in patients with menopausal syndrome of yin deficiency and liver hyperactivity.Methods:Ninety patients with menopausal syndrome of yin deficiency and liver hyperactivity who visited Shanxi Traditional Chinese Medical Hospital from January 2019 to January 2020 were enrolled and randomly divided into a control group and an observation group according to a random number table，with 45 patients in each group.The control group was treated with oral Remifemin Tablets，while the observation group received the combined treatment of Zishui Qinggan Decoction and Remifemin Tablets.Both groups received continuous treatment for 12 weeks.At 4 weeks，8 weeks，and 12 weeks of treatment，the Kupperman Menopausal Index(KMI) scores，Menopause-Specific Quality of Life(MENQOL) scores，and laboratory indicators were compared between the two groups.The therapeutic efficacy of traditional Chinese medicine(TCM) syndromes and adverse reactions in the two groups were analyzed after treatment.Results:After 12 weeks of treatment，the total effective rate was 78.57% in the control group and 95.35% in the observation group，with a statistically significant difference between the two groups(P<0.05).At 12 weeks of treatment，the KMI scores and the scores of all four dimensions of quality of life were lower in the observation group than in the control group(P<0.05).The serum follicle-stimulating hormone(FSH) and estradiol(E2) levels did not differ significantly between the two groups at group admission，4 weeks，8 weeks，and 12 weeks of treatment(all P>0.05).However，at 4 weeks，8 weeks，and 12 weeks of treatment，the serum 5-hydroxytryptamine(5-HT) levels were higher in the observation group than in the control group(all P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Zishui Qinggan Decoction combined with Remifemin Tablets can better improve the clinical symptoms of patients with menopausal syndrome of yin deficiency and liver hyperactivity，improve their quality of life during menopause，not affect their hormone levels，and have mild adverse reactions.It is superior to the use of Remifemin Tablets alone.