To explore the clinical characteristics and application rules of Tenghuang Jiangu Tablets in the treatment of knee osteoarthritis(KOA) patients in the real world based on the method of “Study project for the case registration of Tenghuangjiangu tablets in the treatment to osteoarthritis of the knee”，and analyze the advantages and medication characteristics of Chinese patent medicines in the treatment of KOA.Methods:The registered study data of 2 505 patients from 43 hospitals in China from September 2019 to January 2021 were included in this study and used to analyze the clinical characteristics and medication rules of the patients in general and at different stages.Results:The 2 505 patients included 1 717 females and 788 males，with the mean age of(60.54±6.80) years old and the mean body mass index of(24.05±2.74) kg/m2.Among the patients，2 439 and 66 patients were in remission and attack，respectively，and no patient was in recovery.Most of the patients were rated in Kellgren-Lawrence grade II.In most cases，Tenghuang Jiangu Tablets were administrated for 8 weeks，3 to 6 tablets each time，2 times/day，with the average total dosage of(444.41±164.72) tablets.Adverse reactions occurred in 33 patients.Complicated diseases occurred in 452 KOA patients.Among the 2 505 patients，1 471 patients were treated with Tenghuang Jiangu Tablets alone，and 1 034 patients with Tenghuang Jiangu Tablets combined other drugs.The commonly used other drugs include oral western medicines，oral Chinese patent medicines，western medicines for joint cavity injection，and Chinese patent medicines for external use.The patient age and complicated diseases varied in different disease stages(P<0.05).Conclusion:More women than men with KOA in the real world were treated with Tenghuang Jiangu Tablets.Most patients were in the K-L grade II and remission，and the patients in attack mostly had older age.The usage and dosage of Tenghuang Jiangu Tablets were consistent with expert consensus.The common drugs used in combination with Tenghuang Jiangu Tablets included oral western medicines，oral Chinese patent medicines，western medicines for joint cavity injection，and Chinese patent medicines for external use，which demonstrated good security.